03 · Biostimulators and biorevitalization
Harmonyca: hyaluronic acid and calcium hydroxylapatite in a single product
Harmonyca (hyaluronic acid and calcium hydroxylapatite) is an injectable that combines, in the same gel, hyaluronic acid and microspheres of calcium hydroxylapatite. The hyaluronic acid provides support and volume, and the hydroxylapatite stimulates collagen production over the following months. It is indicated for laxity and volume loss of the face, for support and skin quality. At Yamagata Dermatologia, in Ipanema, Rio de Janeiro, it is applied by dermatologists after a medical evaluation.

- Duration
- About 1 hour
- Anesthesia
- Numbing cream and anesthetic in the gel itself
- Result
- Immediate, with progressive improvement
- How long it lasts
- Can exceed 1 year
How it works
Harmonyca is called a hybrid injectable because it combines two active ingredients with complementary functions. Hyaluronic acid, the base of the gel, provides support and volume right after the application. The calcium hydroxylapatite microspheres, distributed in the gel, stimulate fibroblasts to produce collagen, which improves skin firmness and quality over the following months.
As a result, a single procedure acts on immediate support and on progressive skin improvement, focusing on the midface and the facial contour.
Indications
- Facial skin laxitySagging of the midface and loss of facial firmness.
- Volume loss and foldsVolume loss in the cheeks and nasolabial folds.
- Facial contour and double chinLoss of jawline definition.
Treated areas
FaceCheeks (malar area) · Midface · Jawline · Preauricular area (in front of the ear)
What a session is like
The doctor assesses the face, defines the support points and marks the areas. After cleaning and applying a numbing cream, the product is applied with a needle or cannula. The gel contains anesthetic in its formula, which makes the application more comfortable.
Recovery
There may be swelling, tenderness and small bruises in the first few days. You can return to your activities on the same day.
Sessions and results
The result is visible right after the application and develops over the following months as collagen is produced. The number of sessions and the interval between them depend on the dermatologist's individual evaluation and on each patient's clinical concern. The effect can last more than a year and varies from person to person.
Contraindications
Harmonyca (hyaluronic acid and calcium hydroxylapatite) is not recommended during pregnancy and breastfeeding, on the lips or under the eyes, over infections or active inflammation in the area, or for people allergic to the product's components. Active autoimmune diseases and previous permanent fillers require evaluation.
At the evaluation, the dermatologist reviews your health history, current medications and previous procedures to confirm the indication.
All procedures are recommended and performed after an individual medical evaluation. Results vary from person to person.
Questions
Frequently asked questions
What is the difference between Harmonyca (hyaluronic acid and calcium hydroxylapatite) and a regular filler?
A regular filler, with hyaluronic acid only, restores volume. Harmonyca adds the collagen stimulation of calcium hydroxylapatite to that effect, which also improves skin firmness and quality over the months.
Can Harmonyca (hyaluronic acid and calcium hydroxylapatite) be dissolved?
Only partially. Hyaluronidase dissolves the product's hyaluronic acid, but not the calcium hydroxylapatite microspheres. For this reason, planning and injection technique are especially important.
When do the results show?
Support and volume are noticed right after the application. The improvement in firmness, from new collagen, appears gradually over two to three months.
Can Harmonyca (hyaluronic acid and calcium hydroxylapatite) be applied to the lips or under the eyes?
No. Because it contains calcium hydroxylapatite, the product is not indicated for these areas, which are treated with pure hyaluronic acid.
Team
Medical team
See also
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